10 Best Calming Products For Cats 2025 in the United States

The Purina Pro Plan Veterinary Supplements Calming Care Cat Supplements are well-regarded, with the brand being the number one veterinarian-recommended cat probiotic. This product uses a proprietary probiotic strain (BL999) designed to help manage stress and anxious behaviors in cats. It comes in a powder form with a liver flavor, which might appeal to many cats, making it relatively easy to administer by mixing it with their food.

The product claims to support positive behaviors, like playing and seeking social contact, while also helping to manage stress-related hormones like cortisol and support a healthy immune system. Each box contains 30 packets, enough for a month's supply, as it is recommended to give one packet daily. However, it can take up to six weeks to notice the full effects of the supplement, which might require some patience from pet owners.

Safety precautions indicate that this supplement is for cats only and should be used under the supervision of a veterinarian, particularly because the safety for pregnant cats or those intended for breeding has not been established. This could be a good option for cats that are prone to anxiety or stress, but it might not be the best fit for owners looking for more immediate results or those with pregnant cats.

The Comfort Zone Multi Cat Calming Diffuser Refills are a drug-free, fragrance-free solution designed to reduce tension and aggressive behaviors in multi-cat households. This product uses calming pheromones to help manage issues like swatting, scratching, and fighting. The refills are compatible only with Comfort Zone diffusers, which are reusable for up to 12 months. Each refill lasts about 30 days, providing up to six months of continuous calming support with the included six-pack value set.

The diffusers effectively cover up to 400 square feet, making them suitable for larger rooms where your cats spend most of their time. Safety is a key aspect, with the product meeting Intertek electrical safety and certified to UL standards, and an automatic shut-off feature to prevent overheating. While the diffuser is easy to use, it requires proper placement—upright and not obstructed by furniture for optimal performance.

Users should note that the product might not work with other brands’ diffusers and must be replaced monthly for consistent effectiveness. Additionally, the lack of fragrance might be a plus for some, but it could also mean it's less noticeable when it's working. This calming solution may be particularly beneficial for households with more than one cat experiencing behavioral issues.

The FELIWAY Optimum diffuser uses synthetic pheromones designed to mimic natural calming signals cats give each other, making it a drug-free and non-sedating option. This makes it a good fit for cat owners looking for a safe, gentle way to reduce stress-related behaviors like spraying, scratching, and fearfulness. It works continuously for up to 30 days per vial, covering about 700 square feet, which suits most home environments with one or two diffusers. It’s simple to use—just plug into an outlet with some open space around it for best effect—and designed specifically for cats, so it won’t affect people or other pets. Users report significant reductions in common stress behaviors, which supports its effectiveness.

Because it relies on pheromones, results can vary from cat to cat depending on individual preferences and sensitivity. The diffuser must be replaced every six months and only with official FELIWAY refills, which adds some ongoing cost and limits flexibility with third-party products. Placement matters, too; it shouldn’t be hidden behind furniture or near litter boxes to work well.

While some cats respond quickly, others might take longer or need additional calming support. FELIWAY Optimum is a trusted, veterinarian-recommended calming product best suited for cat owners who want a safe, easy-to-use, and steady way to ease their cat’s stress without medication, though it requires monthly maintenance and careful placement for best results.